History Sharkliveroil l What is squalene? l The Role of Squalene in Health l Dr. Carl A. Luer
Dr. William Lane interview by dr. Passwater l Dr. William Lane l Dr. Bikul Das l G.S. Kelly Clinical uses
Dr. William Lane vision about Shark Cartilage and Cancer
According to I. William Lane, author of "Sharks Don't Get Cancer" and a leading proponent of shark cartilage as an effective cancer treatment, ingestion of shark cartilage inhibits angiogenesis. In lay terms, what this means is that cartilage apparently reduces the creation of a network of blood vessels around a tumor, and therefore prevents it from growing or spreading.
A number of websites (including those owned by William Lane and his son, Andrew Lane) and health food stores sell shark cartilage pills and claim that they are effective cancer (and/or arthritis) therapies.
Potential consumers, however, should be aware that the effectiveness of shark cartilage has not been demonstrated scientifically. They should also know that although I. William Lane is popularly known as "Dr. Lane", he has a Ph.D. in agricultural biochemistry rather than a M.D. Also, he was a vice-president at W.R. Grace, which is an important defendant in many asbestos cancer lawsuits.
Potential consumers should also be aware that, in December 1999, the U.S. Department of Justice filed a lawsuit against Lane Labs-USA and Andrew Lane (its president and the son of I. William Lane) in the U.S District Court for the District of New Jersey. The FDA sought to stop them from marketing shark cartilage with claims that it is an effective cancer therapy.
Cartilage is a type of tissue found in the skeleton. Interestingly, the skeletons of sharks are almost entirely cartiliginous and, as far as we know, the cancer rate in sharks for certain types of tumors appears to be low. Shark and bovine cartilage, and possibly other types, contain angiogenic inhibitors - compounds that halt the creation of blood vessels. This combination of facts means that shark and other types of cartilage are of considerable interest to medical researchers.
However there is, at this time, no clinical evidence that swallowing powdered shark cartilage is an effective cancer treatment or that it inhibits angiogenesis. The cartilage is digested by the body's gastric system, rather than absorbed (with its antiangiogenic inhibitors) into the bloodstream.
Although there are several antiangiogenesis clinical trials in progress they are all in very early stages of testing. These drugs are not administered orally.
Before anyone with mesothelioma takes shark cartilage he/she should discuss this matter with his/her treating physician. There are a number of reasons to do this, including the need to ensure that he/she obtains only clinical-grade cartilage and the possibility of side-effects.
- The American Cancer Society information page on shark cartilage
- A clinical trial using shark cartilage
- Check cartilage information sheet from the University of Texas Complementary/Integrative Medicine Education Resources (at the University of Texas M.D. Anderson Cancer Center) found under "Review of Therapies" - under Biologic/Organic/Pharmacologic Therapies.
- The Quackwatch report on shark cartilage
- Contact the American Cancer Society at 1-800-ACS-2345.
WILLIAM LANE, Ph.D. holds his B.S. and M.S. Degrees in Nutrition from Cornell University and his Ph.D. in Biochemistry and Nutrition from Rutgers University where he worked under two Nobel Prize winners. He recently was awarded the honorary degree of Doctor of Integrated Medicine from The Florida College of Integrative Medicine in Orlando, Florida where a new School of Naturapathic Medicine is being organized which will be named after Dr. Lane. In August of this year Dr. Lane was invited down to the South American nation of Peru to assist them in utilizing the plants and flora which were widely used by the Incas as effective medicines before the advent of Western Chemical Medicine.
Dr. Laneís research is behind the interest in Shark Cartilage which is now the subject of a 600 patient, phase 3, seven million dollar study largely funded by the NIH and being run by the Mayo Clinic on advanced breast and colon cancer patients. Dr. Lane directed a human study which was successfully run in Cuba on 29 advanced cancer patients who had failed all conventional treatments and were receiving shark cartilage as the only medication. This was positively featured on CBSís 60 Minutes with Mike Wallace in February and July 1993.
Dr. Lane has co-authored 4 books: Sharks Donít Get Cancer (1993), Sharks Still Donít Get Cancer (1996), The Skin Cancer Answer (1998) and Immune Power (1999). His work in Alternative Therapies and Anti-Aging has helped to increase the acceptance of natural treatments in complimenting mainstream medicine.
Dr. Lane will be talking about a new, highly effective test for cancer to measure the effectiveness of therapies as well as a screening test for the presence of cancer. The commonly used tumor markers and their reliability compared to this new test, called the CARE TEST will be discussed.
He will speak on The New Innovative Cancer CARE Test.
Some sources you can seea summary in PDF-files. You need Adobe Acrobat Reader.
Sources and references Squalene and haaienleverolie
1. Berger S.M.: 'Forever Young', 1ste ed., 1989.
2. Tsjujimoto M., Toyam Y., 1992: ' Unsaponifiable Constituents (higher alcohol) of the liver oil of the sharks and rays'. Chem Umschau 29: 27 - 29, 43 - 45
3. Dr. Conrado O. Venzon, 'The Precious Oil of the Deep-Sea Shark', Worldwide Publ.Services Quezon City, Philippines.
4. 'The Healer Shark', Neil Solomons MD.Ph.D. and Richard Passwater, Ph.D. 1998
5. Brohult, Astrid, 1963: 'Alkylglycerols and their use in Radiation Treatment', Acta. Radiol. Suppl. 223: 7 - 99, Stockholm.
6. Dr. William Lane Comac, 'Sharks don't Get Cancer', 1992.
7. ' Fish Oil May Ease Arthritis Pain'. Med. World News July 14, 1986, p. 9.
8 Glausinz: 'The Secret Healing Power of Sharks', The Medicine Discoverer Magazine, January 1994.
9. Prof. dr. J. de Vries, Hart- en vaatziekten vormen samen met kanker de belangrijkste doodsoorzaak in de westerse wereld. Studies wijzen uit dat visolie unieke vetzuren bevat die preventief werken. Waar blijven de aanbevelingen van volksgezondheid? Natuur en techniek 65, 12 1997
10. Kromhout, Daan, Bosschieter, Edward B. and Coulander, Cor de Lezenne, 1985: 'The Inverse relationship Between Fish Oil Consumption and 20-Year old Mortality from Coronary Health Diseases'.
11. Takashi Yokota M.D., 'The Miracle of Squalene (Cures Cancer & Modern Diseases)'
The Medicine Discoverer, January 1994, 'The Secret Healing Power of Sharks'.
13. Martin-Moreno JM, Willett WC, Gorgojo L et al. Dietary fat, olive oil intake and breast cancer risk. Int.J Cancer 1994;58:
14. Trichopoulou A, Katsouyanni K, Stuver S et al. Consumption of olive oil and specific food groups in relation to breast cancer risk in Greece. J Natl.Cancer Inst. 1995;87:110-6.
15. Landa MC, Frago N, Tres A. Diet and the risk of breast cancer in Spain. Eur.J Cancer Prev. 1994;3:313-20.
16. Franceschi S, Favero A, Decarli A et al. Intake of macronutrients and risk of breast cancer. Lancet 1996;347:1351-6.
17. La Vecchia C, Negri E. Fats in seasoning and the relationship to pancreatic cancer. Eur.J Cancer Prev. 1997;6:370-3.
18. Porter, Ph.D. Squalene Monooxygenase, University of Kentucky
19. Newmark HL. Squalene, olive oil, and cancer risk: a review and hypothesis. Cancer Epidemiol Biomarkers Prev 1997
20. Rao CV, Newmark HL, Reddy BS. Chemopreventive effect of squalene on colon cancer. Carcinogenesis 1998;19:287-290
21. Nakagawa M, Yamaguchi T, Fukawa H, et al. Potentiation by squalene of the cytotoxicity of anticancer agents against culture mammalian cells and murine tumor. Jpn J Cancer Res 1985;76:315-320.
22. Asnis DS, Saltzman HP, Melchert A. Shark oil pneumonia. An overlooked entity. Chest 1993;103:976-977.
23. Yamaguchi T, Nakagawa M, Hidaka K et al. Potentiation by squaleen of antitumor effect of 3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-1-(2-chloroethyl)-nitros ourea in a murine tumor system. Jpn.J Cancer Res. 1985;76:1021-6.
24. Smith TJ, Yang GY, Seril DN, Liao J, Kim S. Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis by dietary olive oil and squaleen. Carcinogenesis 1998;19:703-6.
25. Smith, T. J., Kim, S., Lee, M. J., Yang, G. Y., Newmark, H. L., and Yang, C. S. Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NKK)-induced lung tumorigenesis and DNA oxidation by dietary squaleen. Proceedings of the American Association for Cancer Research 40, 262. 1999. Ref Type: Journal (Full)
26. Dr. Bikul Das. The Science behind Squalene. The Human Antioxidant. 2000. Toronto Canada
27. Kelly GS. Squaleen and its potential clinical uses. Altern.Med Rev. 1999;4:29-36.
28. Fliesler SJ, Keller RK. Isoprenoid metabolism in the vertebrate retina. Int.J Biochem.Cell Biol. 1997;29:877-94.
29. Strandberg TE, Tilvis RS, Miettinen TA. Metabolic variables of cholesterol during squaleen feeding in humans: comparison with cholestyramine treatment. J Lipid Res. 1990;31:1637-43.
30. Kohno Y, Egawa Y, Itoh S, Nagaoka S, Takahashi M, Mukai K. Kinetic study of quenching reaction of singlet oxygen and scavenging reaction of free radical by squaleen in n-butanol. Biochim.Biophys.Acta 1995;1256:52-6.
31. Miettinen TA, Vanhanen H. Serum concentration and metabolism of cholesterol during rapeseed oil and squaleen feeding. Am J Clin.Nutr. 1994;59:356-63.
32. Chan P, Tomlinson B, Lee CB, Lee YS. Effectiveness and safety of low-dose pravastatin and squaleen, alone and in combination, in elderly patients with hypercholesterolemia. J Clin.Pharmacol. 1996;36:422-7.
33. Smith TJ. Squaleen: Potential chemopreventive agent by squalene. Expert.Opin.Investig.Drugs 2000;9:1841-8.
34. Martin-Moreno JM, Willett WC, Gorgojo L et al. Dietary fat, olive oil intake and breast cancer risk. Int.J Cancer 1994;58:
35. Luer, C. A. et al: (In Vitro Metabolism Of The Proximate Carcinogen Aflatoxin-B 1 By Liver Portions Of The Calf, Nurse Shark And Clearnose Skate) Fed. Froc. 46:2 290, 1987
36. Trichopoulou A, Katsouyanni K, Stuver S et al. Consumption of olive oil and specific food groups in relation to breast cancer risk in Greece. J Natl.Cancer Inst. 1995;87:110-6.
37. Paul Terry, Paul Lichtenstein, Maria Feychting, Anders Ahlbom, Alicja Wolk, Vol 357, June 2, 2001 The Lancet
38. Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors a and g. Steven A. Kliewer, Scott Sundseth et al. Nat. Academy of Sciences of the USA 1997
39. Joseph Vamecq, Norbert Latruffe, Vol 354, July 10, 1999 The Lancet
40. E. Mueller, P. Sarraf , ÖÖ Bruce M. Spiegelman. Molecular Cell. Vol 1, 465-470, February, 1998
Some sources you can see inPDF-files. You need Adobe Acrobat Reader.
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