History Sharkliveroil l What is squalene? l The Role of Squalene in Health  l  Dr. Carl A. Luer

Dr. William Lane interview by dr. Passwater  Dr. William Lane  l  Dr. Bikul Das  l  G.S. Kelly Clinical uses

Is squalene behind olive oil's magic?

By Diana Swift

Increased consumption linked to decrease in cancer risk

NEW ORLEANS - What is it in olive oil that seems to protect against cancer where other vegetable lipids promote it?

It could be its unusually high levels of the unsaturated terpene hydrocarbon known as squalene, said Harold Newmark, a former pharmaceutical industry chemist and now a researcher with the Strang Cancer Research Laboratory at Rockefeller University in New York and the Laboratory for Cancer Research at Rutgers University in Piscataway, N.J.

"Epidemiologic studies of Mediterranean populations show that increased intake of olive oil is associated with a decrease or no increase in cancer risk, despite an overall higher lipid intake," he said at his poster exhibit at the American Association for Cancer Research meeting.

Studies in Spain and Greece, for instance, have found markedly reduced breast cancer risk in women consuming the highest amounts of monounsaturated fat; and in Italy, where olive oil represents 80% of edible oil consumed, researchers have noted a trend to decreased pancreatic cancer risk with increased frequency of oil intake.

Moreover, animal experiments in high dietary fat and cancer show that, unlike other fats, olive oil has either no promoting effect or a protective effect against chemically induced tumors.

"Our hypothesis was that the high squalene content of olive oil is a major factor in its risk-reducing effect," Newmark said.

Dietary squalene appears to decrease the number of aberrant crypt foci in colon cancer studies in rats, while topical squalene applied to mouse skin tumors markedly reduces the promoting effect of chemical carcinogens. (Newmark cautions not to rely on olive oil as a sunscreen.)

He believes the mechanism may be squalene's ability to block the activity of HMG-CoA reductase, the enzyme involved in cholesterol synthesis. "This reduces the availability of farnesyl pyrophosphate for the prenylation of the ras oncogene. This is a process that relocates the oncogene in cell membranes and is required to activate the signal-transducing function of ras."

In the U.S., he said, dietary consumption of squalene is only about 30 mg/d, although some squalene is produced by endogenous biosynthesis. "In Mediterranean countries, olive oil intake averages 12 kilos per person per year and so the daily range is probably more like 200 mg to 400 mg," he said.

  Why is Squalene and Sharkliveroil recommmended?  


Why is shark liver oil especially recommended as a preventive for children, pregnant women aged people; How and which substance from shark liver oil effects the complexion, fresh look, fading of wrinkles, vitality…;
Why had the benefits of shark liver oil been kept a secret in the countries of the Far East and Scandinavia; What are the most common diseases caused by radiation and what do doctors and scientists recommend a protection against its effects after they have emerged;Which diseases emerge as the result of immunity loss; “A moving story of a Spanish pilot, Luis de la Hoza, about a massacre of an entire nation: …
They were bombed with new types of weapon, poisonous gases that weaken the immune system, bombs that pollute the soil, field poison, bombs causing sterility…

After the dreadful bombing campaigne in Kosovo and some towns in Serbia (Bor, Kragujevac, Pancevo, Novi Sad, Niš) with the uranium ammunition there has been reported terrifying radiation.

Today, when scientists and doctors have completely investigated the miraculous effects of shark liver oil in the treatments of various diseases, the fantastic strenghtener of the human immune system and as a preventive against various diseases, shark liver oil has gained recognition on the revolutionary field of natural medicine, especially when taken into account the already existing therapies in the official medicine for certain diseases which may bring unwanted effects, and which are sometimes more destructive that the illness itself. The prediction of physicists that by year 2000 every other man in the USA is going to suffer from cancer, caused panic among the researchers who are trying to find a cure, and even rather a preventive for healthy people for this disastrous sisease. Since 1986 shark liver oil has been used in Germany as an unavoidable means for treating cases of oncological lung diseases.
Find out why this may be the most important book on your health you will read this year.



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Sources and references Squalene and haaienleverolie

1. Berger S.M.: 'Forever Young', 1ste ed., 1989.

2. Tsjujimoto M., Toyam Y., 1992: ' Unsaponifiable Constituents (higher alcohol) of the liver oil of the sharks and rays'. Chem Umschau 29: 27 - 29, 43 - 45

3. Dr. Conrado O. Venzon, 'The Precious Oil of the Deep-Sea Shark', Worldwide Publ.Services Quezon City, Philippines.

4. 'The Healer Shark', Neil Solomons MD.Ph.D. and Richard Passwater, Ph.D. 1998

5. Brohult, Astrid, 1963: 'Alkylglycerols and their use in Radiation Treatment', Acta. Radiol. Suppl. 223: 7 - 99, Stockholm.

6. Dr. William Lane Comac, 'Sharks don't Get Cancer', 1992.

7. ' Fish Oil May Ease Arthritis Pain'. Med. World News July 14, 1986, p. 9.

8 Glausinz: 'The Secret Healing Power of Sharks', The Medicine Discoverer Magazine, January 1994.

9. Prof. dr. J. de Vries, Hart- en vaatziekten vormen samen met kanker de belangrijkste doodsoorzaak in de westerse wereld. Studies wijzen uit dat visolie unieke vetzuren bevat die preventief werken. Waar blijven de aanbevelingen van volksgezondheid? Natuur en techniek 65, 12 1997

10. Kromhout, Daan, Bosschieter, Edward B. and Coulander, Cor de Lezenne, 1985: 'The Inverse relationship Between Fish Oil Consumption and 20-Year old Mortality from Coronary Health Diseases'.

11. Takashi Yokota M.D., 'The Miracle of Squalene (Cures Cancer & Modern Diseases)'

The Medicine Discoverer, January 1994, 'The Secret Healing Power of Sharks'.

13. Martin-Moreno JM, Willett WC, Gorgojo L et al. Dietary fat, olive oil intake and breast cancer risk. Int.J Cancer 1994;58:

14. Trichopoulou A, Katsouyanni K, Stuver S et al. Consumption of olive oil and specific food groups in relation to breast cancer risk in Greece. J Natl.Cancer Inst. 1995;87:110-6.

15. Landa MC, Frago N, Tres A. Diet and the risk of breast cancer in Spain. Eur.J Cancer Prev. 1994;3:313-20.

16. Franceschi S, Favero A, Decarli A et al. Intake of macronutrients and risk of breast cancer. Lancet 1996;347:1351-6.

17. La Vecchia C, Negri E. Fats in seasoning and the relationship to pancreatic cancer. Eur.J Cancer Prev. 1997;6:370-3.

18. Porter, Ph.D. Squalene Monooxygenase, University of Kentucky

19. Newmark HL. Squalene, olive oil, and cancer risk: a review and hypothesis. Cancer Epidemiol Biomarkers Prev 1997

20. Rao CV, Newmark HL, Reddy BS. Chemopreventive effect of squalene on colon cancer. Carcinogenesis 1998;19:287-290

21. Nakagawa M, Yamaguchi T, Fukawa H, et al. Potentiation by squalene of the cytotoxicity of anticancer agents against culture mammalian cells and murine tumor. Jpn J Cancer Res 1985;76:315-320.

22. Asnis DS, Saltzman HP, Melchert A. Shark oil pneumonia. An overlooked entity. Chest 1993;103:976-977.

23. Yamaguchi T, Nakagawa M, Hidaka K et al. Potentiation by squaleen of antitumor effect of 3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-1-(2-chloroethyl)-nitros ourea in a murine tumor system. Jpn.J Cancer Res. 1985;76:1021-6.

24. Smith TJ, Yang GY, Seril DN, Liao J, Kim S. Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis by dietary olive oil and squaleen. Carcinogenesis 1998;19:703-6.

25. Smith, T. J., Kim, S., Lee, M. J., Yang, G. Y., Newmark, H. L., and Yang, C. S. Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NKK)-induced lung tumorigenesis and DNA oxidation by dietary squaleen. Proceedings of the American Association for Cancer Research 40, 262. 1999. Ref Type: Journal (Full)

26. Dr. Bikul Das. The Science behind Squalene. The Human Antioxidant. 2000. Toronto Canada

27. Kelly GS. Squaleen and its potential clinical uses. Altern.Med Rev. 1999;4:29-36.

28. Fliesler SJ, Keller RK. Isoprenoid metabolism in the vertebrate retina. Int.J Biochem.Cell Biol. 1997;29:877-94.

29. Strandberg TE, Tilvis RS, Miettinen TA. Metabolic variables of cholesterol during squaleen feeding in humans: comparison with cholestyramine treatment. J Lipid Res. 1990;31:1637-43.

30. Kohno Y, Egawa Y, Itoh S, Nagaoka S, Takahashi M, Mukai K. Kinetic study of quenching reaction of singlet oxygen and scavenging reaction of free radical by squaleen in n-butanol. Biochim.Biophys.Acta 1995;1256:52-6.

31. Miettinen TA, Vanhanen H. Serum concentration and metabolism of cholesterol during rapeseed oil and squaleen feeding. Am J Clin.Nutr. 1994;59:356-63.

32. Chan P, Tomlinson B, Lee CB, Lee YS. Effectiveness and safety of low-dose pravastatin and squaleen, alone and in combination, in elderly patients with hypercholesterolemia. J Clin.Pharmacol. 1996;36:422-7.

33. Smith TJ. Squaleen: Potential chemopreventive agent by squalene. Expert.Opin.Investig.Drugs 2000;9:1841-8.

34. Martin-Moreno JM, Willett WC, Gorgojo L et al. Dietary fat, olive oil intake and breast cancer risk. Int.J Cancer 1994;58:

35. Luer, C. A. et al: (In Vitro Metabolism Of The Proximate Carcinogen Aflatoxin-B 1 By Liver Portions Of The Calf, Nurse Shark And Clearnose Skate) Fed. Froc. 46:2 290, 1987
36. Trichopoulou A, Katsouyanni K, Stuver S et al. Consumption of olive oil and specific food groups in relation to breast cancer risk in Greece. J Natl.Cancer Inst. 1995;87:110-6.

37. Paul Terry, Paul Lichtenstein, Maria Feychting, Anders Ahlbom, Alicja Wolk, Vol 357, June 2, 2001 The Lancet

38. Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors a and g . Steven A. Kliewer, Scott Sundseth et al. Nat. Academy of Sciences of the USA 1997

39. Joseph Vamecq, Norbert Latruffe, Vol 354, July 10, 1999 The Lancet

40. E. Mueller, P. Sarraf , …… Bruce M. Spiegelman. Molecular Cell. Vol 1, 465-470, February, 1998

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