Dr. Bikul Das
The Science behind Squalene
Dr. Bikul Das is a Research Fellow at the University of Toronto's
Hospital for Sick Children, one of the world's most prestigius medical
centers. Dr. Das began his career in molecular biology and cancer
research after several years of clinical practice in Bhutan and India.
His studies in oxidative stress and his concern for the impact of
pollution on
human health led him first to the subject of isopreniod antioxidants and
subsequently to the Isopreniod Squalene, with its recently discovered
importance in preventive medicine.
Dr. Das is currently working on a cancer research project in the
Department of Hematology and Oncology at the same hospital.
This book shows that the subject of Squalene has been highly
underestimated, and contains truly innovative thinking about the activity
of oxidants and anitoxidants. Dr. Das hypothesizes that the presence of
Squalene in human
skin is an evolutionary requirement and raises the question of whether
Squalene metabolism is threatened by environrmental pollution. This
clearly presented book methodically describes the dynamic interconnection
of
oxidant-antioxidant balance, evolution and environmental change. [Dr.
George P. Konok, M.D.MSC.FRCSC.FACE. Professor of Surgery. Department of
Surgery, Royal University Hospital, Saskatoon. Canada.
Squalene plays a major role in the protection and enhancement of human
skin. Dr. Bikul Das has written an authoritive book that brings together
the facts about a remarkable substance that has remained unclear to the
medical
community for far too long. Dr. Vicki Belo. M.D,Dermatologic Surgeon.
Cosmetic Surgeon, Founder Belo Medical Group. Manila, Philippines. The
Medical community today puts great importance on the damgae caused by
oxygen radicals and my own research has confirmed the positive effects of
Squalene. This book and its presentation of Squalene's biochemical
properties are immensely valuable, particularly in the West, where it is
still not fully appreciated. Takashi Yokota. PhD. Yokota Health Institute,
Japan.
Methods developed by Dr.F.X.Mayr have shown that antioxidant-based
cocktailsaid detoxification and improve tissue regeneration. Dr. Das's
important book has enriched our understanding of cellular regeneratin and
shown how Squalene contributes to a balanced response to toxins, oxidants
and other threats. Richard Kogenlnig, M.D. Health Centre Lanserhof, Lans,
Austria.
Like Glutathione[GSH] Squalene is one of the few antioxidants manufactured
within the body, both of which detoxify, help balance our protective
metabolisms and protect us from other threats. In this book, Dr. Bukul
Das reveals that medical science has in faxt clarified much more about
Squalene than was preivously realized. By uncovering and combining many
research findings into a detailed overview, his book has advanced our
understanding by leaps and bounds. Dr. Jimmy Gutman, M.D.FACEP, Montreal,
Canada. Author of Glutathione[GSH-Your Body's Most Powerful Healing Agent.
Despite extensive research, Squalene has remained largely unknown in the
West. In this book, Dr. Bikul Das gathers all known data on the subject
and presents them clearly. He provides valuable insight into the crucial
subject of oxidant-antioxidant balance and evidence for Squalene's
anti-cancer and cholesterol-lowering effects.-Allan Somersall, PhD.M.D.,
Toronto, Canada. Author of Breakthrough in Cell-Defense and Nature's
Goldmine
Some sources you can see
a summary in PDF-files. You need Adobe Acrobat Reader.
Sources and references Squalene and haaienleverolie
1. Berger S.M.: 'Forever Young', 1ste ed., 1989.
2. Tsjujimoto M., Toyam Y., 1992: ' Unsaponifiable Constituents (higher alcohol) of the liver oil of the sharks and rays'. Chem Umschau 29: 27 - 29, 43 - 45
3. Dr. Conrado O. Venzon, 'The Precious Oil of the Deep-Sea Shark', Worldwide Publ.Services Quezon City, Philippines.
4. 'The Healer Shark', Neil Solomons MD.Ph.D. and Richard Passwater, Ph.D. 1998
5. Brohult, Astrid, 1963: 'Alkylglycerols and their use in Radiation Treatment', Acta. Radiol. Suppl. 223: 7 - 99, Stockholm.
6. Dr. William Lane Comac, 'Sharks don't Get Cancer', 1992.
7. ' Fish Oil May Ease Arthritis Pain'. Med. World News July 14, 1986, p. 9.
8 Glausinz: 'The Secret Healing Power of Sharks', The Medicine Discoverer Magazine, January 1994.
9. Prof. dr. J. de Vries, Hart- en vaatziekten vormen samen met kanker de belangrijkste doodsoorzaak in de westerse wereld. Studies wijzen uit dat visolie unieke vetzuren bevat die preventief werken. Waar blijven de aanbevelingen van volksgezondheid? Natuur en techniek 65, 12 1997
10. Kromhout, Daan, Bosschieter, Edward B. and Coulander, Cor de Lezenne, 1985: 'The Inverse relationship Between Fish Oil Consumption and 20-Year old Mortality from Coronary Health Diseases'.
11. Takashi Yokota M.D., 'The Miracle of Squalene (Cures Cancer & Modern Diseases)'
The Medicine Discoverer, January 1994, 'The Secret Healing Power of Sharks'.
13. Martin-Moreno JM, Willett WC, Gorgojo L et al. Dietary fat, olive oil intake and breast cancer risk. Int.J Cancer 1994;58:
14. Trichopoulou A, Katsouyanni K, Stuver S et al. Consumption of olive oil and specific food groups in relation to breast cancer risk in Greece. J Natl.Cancer Inst. 1995;87:110-6.
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18. Porter, Ph.D. Squalene Monooxygenase, University of Kentucky
21. Nakagawa M, Yamaguchi T, Fukawa H, et al. Potentiation by squalene of the cytotoxicity of anticancer agents against culture mammalian cells and murine tumor. Jpn J Cancer Res 1985;76:315-320.
22. Asnis DS, Saltzman HP, Melchert A. Shark oil pneumonia. An overlooked entity. Chest 1993;103:976-977.
24. Smith TJ, Yang GY, Seril DN, Liao J, Kim S. Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis by dietary olive oil and squaleen. Carcinogenesis 1998;19:703-6.
25. Smith, T. J., Kim, S., Lee, M. J., Yang, G. Y., Newmark, H. L., and Yang, C. S. Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NKK)-induced lung tumorigenesis and DNA oxidation by dietary squaleen. Proceedings of the American Association for Cancer Research 40, 262. 1999. Ref Type: Journal (Full)
26. Dr. Bikul Das. The Science behind Squalene. The Human Antioxidant. 2000. Toronto Canada
27. Kelly GS. Squaleen and its potential clinical uses. Altern.Med Rev. 1999;4:29-36.
28. Fliesler SJ, Keller RK. Isoprenoid metabolism in the vertebrate retina. Int.J Biochem.Cell Biol. 1997;29:877-94.
29. Strandberg TE, Tilvis RS, Miettinen TA. Metabolic variables of cholesterol during squaleen feeding in humans: comparison with cholestyramine treatment. J Lipid Res. 1990;31:1637-43.
30. Kohno Y, Egawa Y, Itoh S, Nagaoka S, Takahashi M, Mukai K. Kinetic study of quenching reaction of singlet oxygen and scavenging reaction of free radical by squaleen in n-butanol. Biochim.Biophys.Acta 1995;1256:52-6.
31. Miettinen TA, Vanhanen H. Serum concentration and metabolism of cholesterol during rapeseed oil and squaleen feeding. Am J Clin.Nutr. 1994;59:356-63.
32. Chan P, Tomlinson B, Lee CB, Lee YS. Effectiveness and safety of low-dose pravastatin and squaleen, alone and in combination, in elderly patients with hypercholesterolemia. J Clin.Pharmacol. 1996;36:422-7.
33. Smith TJ. Squaleen: Potential chemopreventive agent by squalene. Expert.Opin.Investig.Drugs 2000;9:1841-8.
34. Martin-Moreno JM, Willett WC, Gorgojo L et al. Dietary fat, olive oil intake and breast cancer risk. Int.J Cancer 1994;58:
35.
Luer, C. A. et al: (In
Vitro Metabolism Of The Proximate Carcinogen Aflatoxin-B 1 By Liver Portions
Of The Calf, Nurse Shark And Clearnose Skate) Fed. Froc. 46:2 290, 1987
36.
Trichopoulou A, Katsouyanni K, Stuver S et al. Consumption of olive oil and
specific food groups in relation to breast cancer risk in Greece. J
Natl.Cancer Inst. 1995;87:110-6.
37. Paul Terry, Paul Lichtenstein, Maria Feychting, Anders Ahlbom, Alicja Wolk, Vol 357, June 2, 2001 The Lancet
38. Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors a and g
. Steven A. Kliewer, Scott Sundseth et al. Nat. Academy of Sciences of the USA 199739. Joseph Vamecq, Norbert Latruffe, Vol 354, July 10, 1999 The Lancet
40. E. Mueller, P. Sarraf , …… Bruce M. Spiegelman. Molecular Cell. Vol 1, 465-470, February, 1998
Some sources you can see in
PDF-files. You need Adobe Acrobat Reader.
Immuunmodulator
